Kid's Health

Pendred Syndrome: A Rare Genetic Disorder Affecting Children’s Hearing

DiYES International School – Pendred Syndrome is a rare genetic disorder that primarily affects hearing and can also impact the thyroid gland. It is inherited in an autosomal recessive manner, meaning both parents must pass on the defective gene for the child to develop the condition. This disorder is most often diagnosed in childhood, as hearing loss becomes apparent early on. Understanding Pendred Syndrome is crucial for early diagnosis and appropriate management.

What Is Pendred Syndrome?

Pendred Syndrome is a condition that involves both hearing loss and thyroid abnormalities. The hearing loss in this syndrome is caused by inner ear dysfunction, particularly the cochlea, which is responsible for detecting sound vibrations and sending signals to the brain. The condition can lead to progressive sensorineural hearing loss, which means that the hearing ability diminishes over time.

Along with hearing problems, Pendred Syndrome can also affect the thyroid, an important gland responsible for regulating metabolism. Individuals with Pendred Syndrome often develop an enlarged thyroid, a condition known as goiter. This can lead to hypothyroidism, where the thyroid does not produce enough hormones, causing symptoms such as fatigue, weight gain, and cold intolerance.

Symptoms of Pendred Syndrome

The most prominent symptom of Pendred Syndrome is hearing loss. It can range from mild to severe and is typically present from birth. Children with this condition may have difficulty understanding speech, especially in noisy environments. They may also experience delayed language development due to the hearing impairment.

In addition to hearing loss, children with Pendred Syndrome often experience balance issues. The disorder can affect the vestibular system, which is responsible for maintaining balance and coordination. As a result, affected children may have trouble with tasks such as walking or playing sports.

The thyroid problems associated with Pendred Syndrome can also cause a range of symptoms. A goiter may be visible in the neck, and children might experience signs of hypothyroidism, such as sluggishness or difficulty concentrating.

“Read about: The Impact of Psoriasis on Children’s Lives: From Skin to Self-Esteem”

Causes of Pendred Syndrome

Pendred Syndrome is caused by mutations in the SLC26A4 gene. This gene provides instructions for making a protein that is essential for the proper functioning of the inner ear and thyroid. When this gene is mutated, it leads to dysfunction in both the cochlea and the thyroid gland.

The condition is inherited in an autosomal recessive pattern. This means that a child must inherit one copy of the mutated gene from each parent to develop the syndrome. If a person inherits only one mutated gene, they are a carrier of the condition but do not exhibit symptoms.

Diagnosis of Pendred Syndrome

Diagnosis of Pendred Syndrome typically involves a combination of medical history, hearing tests, and genetic testing. A hearing test, or audiogram, is used to assess the degree of hearing loss. Genetic testing can confirm the presence of mutations in the SLC26A4 gene.

In some cases, imaging studies such as a CT scan of the inner ear may be performed to look for specific structural abnormalities, such as enlarged vestibular aqueducts, which are commonly seen in individuals with Pendred Syndrome.

Treatment and Management

There is currently no cure for Pendred Syndrome, but early intervention can help manage the symptoms. For hearing loss, children may benefit from hearing aids, cochlear implants, or other assistive listening devices. These devices can improve their ability to hear and communicate.

Speech therapy is often recommended to help children develop language skills and communication abilities. Early intervention with speech therapy can make a significant difference in language development.

Thyroid problems associated with Pendred Syndrome are treated with thyroid hormone replacement therapy. This treatment helps manage the symptoms of hypothyroidism and can prevent further complications related to the thyroid.

Genetic Counseling

Since this condition is inherited, genetic counseling can provide valuable information for families who have a child with it. A genetic counselor can explain the likelihood of having another child with the disorder and discuss reproductive options.

For parents who are carriers of the condition, prenatal genetic testing is available to determine if a baby has inherited the mutated gene. Early diagnosis through genetic testing can help guide treatment and care decisions for the child.

“Read more: Tina’s Triumph: Rising Above the Trauma of Human Trafficking”

Impact on Daily Life

Children with this condition may face challenges in their daily lives, particularly when it comes to communication and physical activities. However, with appropriate support and treatment, many children can lead active, fulfilling lives. It is important for parents and caregivers to work closely with healthcare providers to address any hearing or thyroid-related issues early on.

As these children grow older, they may require ongoing support in school and social settings. Educational accommodations, such as speech therapy and the use of assistive listening devices, can help ensure that children can succeed academically and socially.

desain ruangpapagencetMarieFranceMedia Mutiara NusantaraSports DailyBahis WonCity Career ServicesLi Cheng Wu XianBCC Ai piao5Dragons E-SportsKuliner Nusantarasolo leveling season 2 sub indogacorone punch man season 3 sub indoKAIJU NO. 8 THE GAMEMelfrisTattoo Supreme IndonesiaPortal KulinerTribun Bolabandar maxwinSahabat NestleExplore NusantaraVedit Creative Studiogacor mudah menang terpercayaThe Mini SocialMonotonixArena Gamerskingligakingligakingligabetslot88Rekomendasi FilmTeori KonspirasiPortal HiburanZippo Collectiontondemo skill s2 sub indodr stone season 4 sub indoDupont LoverKids Care IndonesiaNgabrets GamingCasio GalleryYuk Hidup SehatNarasi KehidupanIrama JiwaZona PopulerGlowstoriaThe Socialist RegisterPixie ForevergacorBlogtubersPremium Biz PostDiy Craft RecipesDizzy PTbrass house austinLink Login Alternatif ZonasixSitus Gacor Nomor 1 ResmiLIGASIX Link Login Alternatifpipemediaa7fr5 bloggeramerican party scassistive technology partnersanoboybebimibroom corn johnnyschamber lains oflondonchaville blogclub de lisacolorado actioneobd toolgarage doors and partsglobal health wiregrb projecthaberedhave seat will travelimmovestinginspa kyotojohn hawkin sunratedkhaleej times jobsleegay lordmclubworldmeet muscatinemidwest garage buildersmonika pandeynet protozopersonal cloudsrippin kitten1 buy celebrex onlinerobert drawsscreemoshahid onlinest francis luck nowsustainability pioneersthe berk shire mallthe blackmore groupthorn ville churchvisit mark twain lakeGarda MediaRadio Senda 1680Rumah JualIndependent ReportgacorOXLIGA Game Online ResmiDaftar Pilihan Situs GacorSultana RoyalDiyes internationalPasmarqueKudakyivABGXMoron CafeElm Sleepidngglink login alternatif idnggidnppRadar PuncakSuper DenoxSerbu DiskonBelanja Lebih Hemat di Alfamartidnppidngg loginoxligaEl Valle GritaHorror YearbookIdnplay NewsGang FlowKDUN RadioTech by AndroidALIVEfmFastCreaSitePrediksi SDY SGP MACAU HK dan Keluaran SDY HK SGPArcadia DailyTop Ten ThingsPlay Source InfoLestanze CafeDiesel SpecialistNGO CS TipCasal Del RavalPitch WarsMeikartagrandal mas residenceAS Roma Forza RomaTutorials PhotoshopPolitikosGayPriderSitus TogelHongkong PoolsMondoRealityaroma masakhidangan istimewainspirasi masakinfo alam indonesiaPT. Tri Karya Cemerlangatalayahttps://institutolobo.org.br/wan solutionfacility servicesrekomendasi balirekomendasi medanliburan pariwisatajelajah alam indonesiawisata alam indonesiacek kesehatanjlpt jakartajlpt bandungjlpt surabayajlpt medanjlpt yogyakartajlpt denpasarjlpt manadoEpiltech jlpt malangjlpt semarangjlpt makassarjlpt palembangjlpt bogorIkabi SurabayaIkabi MedanIkabi PalembangIkabi SemarangIkabi BatamIkabi PekanbaruIkabi BogorIkabi LampungIkabi MalangIkabi BalikpapanIkabi PontianakIkabi BanjarmasinIkabi DenpasarIkabi JambiIkabi SurakartaIkabi ManadoIkabi JayapuraIkabi BengkuluIkabi PaluIkabi SukabumiIkabi KendariIkabi AmbonIkabi DumaiIkabi BinjaiIkabi TegalIkabi SorongIkabi BanjarbaruIkabi Pematang SiantarIkabi SingkawangIkabi ProbolinggoIkabi Tanjung PinangTribun OtomotifTribun TrenHarley Davidson X440bentuk kekecewaan rakyat indonesiaXiaomi 17 siap bersaing dengan iphone 17Ikabi Padang SidempuanIkabi BitungIkabi PasuruanIkabi TernateIkabi GorontaloIkabi SalatigaIkabi LhokseumaweIkabi PalopoIkabi MagelangIkabi SibolgaIkabi MataramIkabi Bekasidunia edukasisolusi ekonomidunia skincarezona life styledunia mistisalam mistiskisah mistisoxligaMosa Mandirisumber misteridunia misteriberita sejarahsejarah masa laluwarisan sejarahsejarah internasionalmisteri sejarahkulit sehatdaily skinskin care hariantren skin carerahasia glowingzona musikhidup trendiarsitek modernrambut sehatrevolusi teknologidunia mahasiswateknologi otomotifBukit Podomoro JakartaLRT City Ciracascomo hacer heladosWala Meron 24 Jammahjong waysgacor luar negerigates of olympus x1000spacemanlink situs gacorhttps://www.troquedeenergia.com/https://reconciliationaccounting.com/https://makmurlux.com/akun303smart leadershttps://noithatvnn.com/https://www.makemoneymakecents.com/sahabat sehatGaya Hidup Sehatdokter keluargaSolusi Kulit SehatRambut Sehat BerkilauRambut Indah SehatTren Hidup SehatInspirasi Lifestyleinspirasi hidup sehatZonaMusikIndonesiaDuniaMusikHitshttps://ikabiambon.org/la/https://ikabibalikpapan.org/la/https://ikabibanjarbaru.org/la/musikkitaInovasiOtomotifRevolusiOtomotifotomotifdigitalgayarumahmurahArsitekKreatifbelajarbersamapendidikanindonesiakebun indonesiatanaman indonesiakebun mandirikarya anak indonesiaide kreatifkreatif tanpa bataskreativitaskudunia kebunhttps://lightwiresystems.com/https://capcusmurni.blog/https://serojamurni.fit/https://clbkmurni.fit/https://greenville-autorepair.com/TX Health WatchPAFI Kabupaten RiauABC del BienestarJosh ShearMedia970PanasMediaCapital PersonalCherry GamesCharleston Market ReportDigiturk BulgariaOrlando Nexus DailyDai Phat Thanh VietnamEntertaina O RamaKent Academy MiangoTwilight MovieSimple Machines ForumAffordable SpaceflightVilanoHeath Ledger CentralPilates PilaScarlot HarlotKpopStarz SmashingSalon Literario LibroamerSimpplermichaelmezonulebaksiuTEKNOKRAT MANDIRI INSTITUTERose Environmental LTDelnamliahKhasanah Sari Bakerywright printingMultan College of PhysiotherapySIPFiberPT Surya Biru Murni AcetyleneGaruda Karya MandiriPesantren Mahasiswa FIRDAUS Malang Lazismu PekalonganPromo Or idSMA Negeri 1 KalasanWright Printingserver luar negeri gacorserver luar negeri maxwinserver thailand gampang maxwinspaceman pragmatic playscatter hitam mahjong waysmahjong ways 1 dan 2KONI PusatKlik TVRISekolah Tinggi Teologia ABDI SABDASTIE BHAKTI PEMBANGUNANJurnal Universitas Hafshawaty Zainul Hasangaya betting sakral kerakesenian praktis raih pecahansering boncos dilive casinosiap beri harta karunstrategi ampuh buka jackpotsultan setelah share linkPelajari 7 Aturan Sederhana Bermain Plingko Highroller ManiacsAwas Kaget Lihat Total BonusnyaDibekali Kemampuan Menyusun Prediksi Toto MacauLangkah Jitu Menganalisa Chance Per PutaranPernah Kecewa Karena Gagal Menjuarai Kontes BlackjackSambut Kejutan Fantastis Sesuai Sistem PerhitunganSempat Diisukan Bakal Pensiun DiniTingkatkan Nilai Hadiah Final Mahjong WarriorTips Menang Mudah Berbekal Akun KhususUpdate Berita Terkini Seputar CMD368 SportsbookPlingko Fortune ThunderBattle of OlympusCheckmate Rush Live CasinoSweet Bonanza PowernudgeMystic Fortune DeluxeSoccer RoulettePoker Dice KasinoMix Parlay SABA SportsPrediksi Odds Handicap NSOFTMode Freespin Mahjong King Royaleini yang dezta gawljam hoki atau teknikkapan waktu terbaik membelilong cuma fokus padamengdikdasmen soroti lonjakan belanjapendekatan analisis statistik sederhanaprofesor sultan cash maniapujian positif dari wargaSpeed Baccarat Versi Pragmaticroulette spin bonanzalive rtp pg softMahjong Wayslive kasino pragmaticmahjong tiger gloryscatter poker empireblack tiger dominionlucky sportsbook blazebaccarat wild genesiskapan harus fokuskombinasi angka dan bonusmemahami waktu yang tepatmindset yang dibutuhkan untuktaktik paling efektif mainMelawan Godaan Multipliercara benar menggunakan fiturjuta dari game mahjongmomentum tim indikator palingrahasia menebak angka kembarhadirkan donasi influencer bandunghimbara resmi salurkan benefitkobarkan semangat prajurit dilautpetualangan dan momentun waktutunjukan komitmen ditengah volatilitasbocoran orang dalam sugarmediasi akrobat buka rencanastabilkan konsentrasi mengeja fiturstop feature untuk balikkanstrategi pasang bola jalanstrategi konsolidasi implementasimodel analitis untuk mengidentifikasisedang dalam mode gilatembus target taruhan kombinasiturun terus tanpa perlawananPokerman Go KasinoPola Naga Hitam Mahjong WaysRoulete Stars ChampionFortune NekoWilds West BanditoMega Baccarat Live CasinoPlingko MegawaysHighroll Spaceman GalaxyPrediksi Odds Mix Parlay SBO Sports Kode BBFS Singapore Poolsakhir dari kemiskinancandyland agar sering masukdriver ojol taklukkan rajajackpot dan strategi optimalisasitiger berhasil dibocorin adminduda keren dijuta per hari dengankini herman hidup enaklangka yang menjadi senjatamenit pemain ini bongkarmodal kecil jadi cuanpenjual sayur pasar mendadaksukses antar driver ojoltengah ketegangan as chinatersakit tahun ini pemainBaccarat Virtualroulette leaguegates of olympus 1000trik bermain mahjong wins 3rekomendasi game live kasinoblackjack spaceman voyagebaccarat wheel royalekingkong scatter treasureroulette lucky tigersportsbook candyland rallyBocoran Major Update Terbaru Mega BaccaratsBawa Pulang Hadiah Gila-GilaanBerbekal Ilmu Tafsir Mimpi Warisan KeluargaKetuk Pintu Keberuntunganmu di Raid Doors RouletteMomen Seru Penuh Kejutan Tak TerdugaNikmati Sesi Streaming 24 Jam Long Hu ClashPunya Ambisi Jadi Dealer Sic Bo EmperorStrategi Raih Profit Fantastis Monopoly Big BallerTingkat Perbandingan Resiko High Low Red BaronTips Ampuh Biar Panen Besar dari Fitur SpesialAkun Pro Myanmargate agar pecah lebihKebijakan baru yang menggetarkanlouvre berhasil raih jackpotSensasi legit bersama mahjongseorang kurir berhasil mantapkansetelah berhasil menjuarai tournamentSetelah sebulan langsung tariksukses bikin dodi jadiWaktu pecahkan ledakan saldoTelusuri Pola Putaran Sweet Bonanza CandylandsBanyak Pilihan Menguntungkan Sedang MenunggumuButuh Berapa Lama untuk Mempelajari AlgoritmeDilengkapi Beragam Promo SpesialHindari Kesalahan Umum PemulaMabar Ceme Keliling Bareng TongkronganMisteri Kombo Perkalian RahasiaPengalaman Praktis Bermain SBOBET VirtualsTampil Bersinar Selama KontesTrik Memaksimalkan Total Bayaran Akhirpakai teknik kodebikin kaya kilat sekaliHampir Gancet dipelukan princeskemenangan mutlak dirayakan pemainmax menjadi saksi pecahnyaRahasia pemicu bonus besarridho tidak menyangka modalTreasure wild pola tarantulaultimate langka prioritaskan wildwaspada ambruknya master blackjackbara kuasai kombinasi hastagkuantitas game pg softmod spin nakal gatepencapaian financial ala wildsecurity pesantren memaximalkan trikdibuat heboh oleh manuverhari dari game microgaminghari ini claim cashbackjenius untuk ubah saldomodal mimim untung maksimalrasakan sensasi wild sempurnawild berderet tak disangka